Hypersensitivity to dapagliflozin or metformin. Temporarily discontinue in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials. Not for patients w/ type 1 DM, diabetic ketoacidosis. Moderate to severe kidney problems. Lactic acidosis. Excessive alcohol intake. Low level of vit B
12. Surgical procedure. Patients who use cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin). Hypoxic states. Loss of control of blood glucose: fever, trauma, infection, or surgery, a temporary loss of glycemic control. Patients receiving loop diuretics or who are vol depleted. Concomitant use of medications known to cause hypoglycemia (insulin, insulin secretagogues, eg, sulfonylurea). Patients w/ UTI (urosepsis & pyelonephritis). Diabetic patients on routine preventative foot care. Pregnancy & lactation. Elderly.
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